Cholesterol Meds

TX

  • Lifestyle changes (diet, fish oil, omega 3 FA, ↑ PA)

  • To ↓ LDL - Statin

    • Add ezetimibe if statin hasn't worked

  • To ↑ HDL - Niacin

  • To ↓ Triglycerides - Fibrates

AIM FOR

    • Low LDL (< 100); DM (< 70)

    • High HDL (> 40)

    • Triglycerides (< 150)

    • Total (< 200)

Statin Intensity

  • High Intensity

  • ↓LDL > 50%

    • Atorvastatin 40-80 mg

    • Rosuvastatin 20-40 mg

  • Moderate Intensity

  • ↓ LDL 30-49%

    • Lovastatin 40-80 mg

    • Pravastatin 40-80 mg

    • Simvastatin 20-40 mg

    • Atorvastatin 10-20 mg

    • Rosuvastatin 5-10 mg

  • Low Intensity

  • ↓ LDL < 30%

    • Pravastatin 10-20mg

    • Lovastatin 20mg

    • Simvastatin 10 mg

Statins

Statins recommended to take at bed-time, especially simvastatin (shortest T1/2)

Niacin

Bile acid sequestrants

Fibrates

Ezetimibe & PCSK9 inhibitors